Approximately 5 years ago, researchers at a major Southeastern University begin working on methods to resolve multi-drug resistant bacterial infections in human burn patients. This research lead to formulation of a potentiating agent that makes otherwise resistant bacteria susceptible to low class antibiotics. The potentiator that has proven effective against the "super" bugs that infect burns will also kill common bacteria associated with ulcer disease and other superficial infections in companion Koi.
FIGURE 1. KOI WITH ULCER INFECTED WITH MULTI-ANTIBIOTIC RESISTANT BACTERIA BEFORE AND 15 DAYS AFTER 5 TO 10 MINUTE DIPS IN TRICIDE-NEO® ON DAYS 1, 2 AND 4.
FIGURE 2. PSEUDOMONAS SP. (A COMMON BACTERIA IN FISH ULCERS) BEFORE AND AFTER EXPOSURE TO TRICIDE-NEO.
To date, we have found Tricide-Neo to be beneficial in treating superficial bacterial infections in fish maintained in both experimental and field conditions. Among the advantages of Tricide-Neo are its ease of use, safety and effectiveness against common gram positive and gram negative bacterial pathogens.
The antibiotic potentiator in Tricide-Neo has a rather interesting mode of activity that facilitates its spectrum of activity. Tricide-Neo creates holes (Figure 2) in the bacterial cell wall which in-turn allows antibiotics to flood the organism, destroys the effectiveness of the bacteria’s efflux pump and facilitates osmotic collapse of the bacterium. Because the potentiator causes direct physical damage to the bacteria, one is able to use less antibiotic than would normally be necessary and exposed bacteria are less likely to develop resistance to the chosen antibiotic. This later fact is particularly important in facilities where use of antibiotics without Tricide-Neo can quickly result in development of populations of bacteria that are resistant to many readily available antibiotics. I am sure that as a Koi enthusiast you are always searching for effective methods to reduce or prevent the evolution of antibiotic resistant bacteria in your fish and ponds.
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